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If out of hours, log into VCentre (please use win/adm-xxxx account) and check if the VMs are running. If the server can't be pinged :
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Follow the steps here: clean up big files
This should already be being monitored and reported upon if it is becoming full , so this scenario should never occur.
Final Step
Please raise ticket with Software Development Support and include the details of the steps taken out of business hours so that detailed analyses of the failure can be carried out.